Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice

Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice

Abstract Rapamycin slows cystogenesis in murine models of polycystic kidney disease (PKD) but failed in clinical trials, potentially due to insufficient drug dosing. To improve drug efficiency without increasing dose, kidney-specific drug delivery may be used. Mesoscale nanoparticles (MNP) selective...

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Bibliographic Details
Main Authors: Shinobu Yamaguchi, Randee Sedaka, Chintan Kapadia, Jifeng Huang, Jung-Shan Hsu, Taylor F. Berryhill, Landon Wilson, Stephen Barnes, Caleb Lovelady, Yasin Oduk, Ryan M. Williams, Edgar A. Jaimes, Daniel A. Heller, Takamitsu Saigusa
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-65830-7

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https://doi.org/10.1038/s41598-024-65830-7

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