Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.

Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.

The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also responsible for DNA damage at oncogenes, leading to their mutation and cancer-associated chromosome translocation in lymphoma. We used fate mappi...

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Bibliographic Details
Main Authors: Philipp C Rommel, David Bosque, Alexander D Gitlin, Gist F Croft, Nathaniel Heintz, Rafael Casellas, Michel C Nussenzweig, Skirmantas Kriaucionis, Davide F Robbiani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3704518?pdf=render

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http://europepmc.org/articles/PMC3704518?pdf=render

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