Identification of a novel NPM1 mutation in acute myeloid leukemia

Identification of a novel NPM1 mutation in acute myeloid leukemia

Abstract Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It is estimated that 25–35% of adult patients with acute myeloid leukemia (AML) carry NPM1 mutations. The classic NPM1 type A mutation occurs in exon 12, which accounts for...

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Bibliographic Details
Main Authors: Yiyi Yao, Xiangjie Lin, Chen Wang, Ying Gu, Jie Jin, Yinghui Zhu, Huafeng Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Experimental Hematology & Oncology
Subjects:
NPM1 mutation
Acute myeloid leukemia
Aberrant cytoplasmic dislocation
Nuclear export signal
Prognosis
Online Access:https://doi.org/10.1186/s40164-023-00449-4

Internet

https://doi.org/10.1186/s40164-023-00449-4

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