Systemic Sympathoexcitation Was Associated with Paraventricular Hypothalamic Phosphorylation of Synaptic CaMKIIα and MAPK/ErK

Systemic Sympathoexcitation Was Associated with Paraventricular Hypothalamic Phosphorylation of Synaptic CaMKIIα and MAPK/ErK

Systemic administration of adrenergic agonist (Isoproterenol; ISOP) is known to facilitate cardiovascular changes associated with heart failure through an upregulation of cardiac toll-like receptor 4 (TLR4). Furthermore, previous studies have shown that cardiac tissue-specific deletion of TLR4 prote...

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Bibliographic Details
Main Authors: Olalekan M. Ogundele, Fernando A. Rosa, Rohan Dharmakumar, Charles C. Lee, Joseph Francis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neuroscience
Subjects:
β2R
MAPK/ErK
CaMKIIα
TLR4
VGLUT2
GABA
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00447/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00447/full

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