Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

BACKGROUND:Enteroendocrine L-cells synthesise and release the gut hormone glucagon-like peptide-1 (GLP-1) in response to food transit. Deletion of the tumour suppressor kinase LKB1 from proglucagon-expressing cells leads to the generation of intestinal polyps but no change in circulating GLP-1 level...

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Bibliographic Details
Main Authors: Sophie R Sayers, Frank Reimann, Fiona M Gribble, Helen Parker, Sagen Zac-Varghese, Stephen R Bloom, Marc Foretz, Benoit Viollet, Guy A Rutter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4806996?pdf=render

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http://europepmc.org/articles/PMC4806996?pdf=render

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