Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the research on the cardiovascular, skin barrier, gastrointestinal, and central nervous systems as well as organ transplantation. Recently, pigs al...

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Bibliographic Details
Main Authors: Yingqi Lin, Caijuan Li, Wei Wang, Jiawei Li, Chunhui Huang, Xiao Zheng, Zhaoming Liu, Xichen Song, Yizhi Chen, Jiale Gao, Jianhao Wu, Jiaxi Wu, Zhuchi Tu, Liangxue Lai, Xiao-Jiang Li, Shihua Li, Sen Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
AAV9
CNS
large animal
pig
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1115348/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.1115348/full

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