Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Transcriptomic analysis of isolates from the malaria parasite (Plasmodium falciparum) in the Greater Mekong Subregion of Southeast Asia identifies gene expression patterns that are correlated with resistance to a common anti-malaria drug, artemisinin.

Bibliographic Details
Main Authors: Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, Nicholas J. White, Nicholas P. J. Day, Abul Faiz, Aung Pyae Phyo, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, François Nosten, Frank Smithuis, Hagai Ginsburg, Lorenz von Seidlein, Khin Lin, Mallika Imwong, Kesinee Chotivanich, Mayfong Mayxay, Mehul Dhorda, Hoang Chau Nguyen, Thuy Nhien Thanh Nguyen, Olivo Miotto, Paul N. Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J. Peto, Tran Tinh Hien, Arjen M. Dondorp, Zbynek Bozdech
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03215-0

Internet

https://doi.org/10.1038/s42003-022-03215-0

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