Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Crystal structures for all enzyme states of leucyl-tRNA synthetase in Neisseria gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps.

Bibliographic Details
Main Authors: Luping Pang, Vladimir Zanki, Sergei V. Strelkov, Arthur Van Aerschot, Ita Gruic-Sovulj, Stephen D. Weeks
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03825-8

Internet

https://doi.org/10.1038/s42003-022-03825-8

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