Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip
Crystal structures for all enzyme states of leucyl-tRNA synthetase in Neisseria gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03825-8 |
| _version_ | 1828143944485044224 |
|---|---|
| author | Luping Pang Vladimir Zanki Sergei V. Strelkov Arthur Van Aerschot Ita Gruic-Sovulj Stephen D. Weeks |
| author_facet | Luping Pang Vladimir Zanki Sergei V. Strelkov Arthur Van Aerschot Ita Gruic-Sovulj Stephen D. Weeks |
| author_sort | Luping Pang |
| collection | DOAJ |
| description | Crystal structures for all enzyme states of leucyl-tRNA synthetase in Neisseria gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps. |
| first_indexed | 2024-04-11T20:07:48Z |
| format | Article |
| id | doaj.art-281daae9c0c5428fb6d7c6d3b73993ac |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T20:07:48Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-281daae9c0c5428fb6d7c6d3b73993ac2022-12-22T04:05:16ZengNature PortfolioCommunications Biology2399-36422022-08-015111210.1038/s42003-022-03825-8Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flipLuping Pang0Vladimir Zanki1Sergei V. Strelkov2Arthur Van Aerschot3Ita Gruic-Sovulj4Stephen D. Weeks5Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU LeuvenDepartment of Chemistry, Faculty of Science, University of ZagrebBiocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU LeuvenMedicinal Chemistry, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, KU LeuvenDepartment of Chemistry, Faculty of Science, University of ZagrebBiocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU LeuvenCrystal structures for all enzyme states of leucyl-tRNA synthetase in Neisseria gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps.https://doi.org/10.1038/s42003-022-03825-8 |
| spellingShingle | Luping Pang Vladimir Zanki Sergei V. Strelkov Arthur Van Aerschot Ita Gruic-Sovulj Stephen D. Weeks Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip Communications Biology |
| title | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip |
| title_full | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip |
| title_fullStr | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip |
| title_full_unstemmed | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip |
| title_short | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip |
| title_sort | partitioning of the initial catalytic steps of leucyl trna synthetase is driven by an active site peptide plane flip |
| url | https://doi.org/10.1038/s42003-022-03825-8 |
| work_keys_str_mv | AT lupingpang partitioningoftheinitialcatalyticstepsofleucyltrnasynthetaseisdrivenbyanactivesitepeptideplaneflip AT vladimirzanki partitioningoftheinitialcatalyticstepsofleucyltrnasynthetaseisdrivenbyanactivesitepeptideplaneflip AT sergeivstrelkov partitioningoftheinitialcatalyticstepsofleucyltrnasynthetaseisdrivenbyanactivesitepeptideplaneflip AT arthurvanaerschot partitioningoftheinitialcatalyticstepsofleucyltrnasynthetaseisdrivenbyanactivesitepeptideplaneflip AT itagruicsovulj partitioningoftheinitialcatalyticstepsofleucyltrnasynthetaseisdrivenbyanactivesitepeptideplaneflip AT stephendweeks partitioningoftheinitialcatalyticstepsofleucyltrnasynthetaseisdrivenbyanactivesitepeptideplaneflip |