SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes

SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes

Summary: Suppressor of cytokine signaling-1 (SOCS1) exerts control over inflammation by targeting p65 nuclear factor-κB (NF-κB) for degradation in addition to its canonical role regulating cytokine signaling. We report here that SOCS1 does not operate on all p65 targets equally, instead localizing t...

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Bibliographic Details
Main Authors: Diego R. Coelho, Flavio R. Palma, Veronica Paviani, Katy M. LaFond, Yunping Huang, Dongmei Wang, Brian Wray, Sridhar Rao, Feng Yue, Marcelo G. Bonini, Benjamin N. Gantner
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Immunology
Molecular mechanism of gene regulation
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223005199

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http://www.sciencedirect.com/science/article/pii/S2589004223005199

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