Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes

Aims: Spinal cord injury (SCI) is a devastating neurological disease that often results in tremendous loss of motor function. Increasing evidence demonstrates that diabetes worsens outcomes for patients with SCI due to the higher levels of neuronal oxidative stress. Mammalian sterile 20-like kinase...

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Bibliographic Details
Main Authors: Weijun Huang, Depeng Wu, Chaoyang Cai, Hui Yao, Zhenming Tian, Yang Yang, Mao Pang, Limin Rong, Bin Liu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
Spinal cord injury (SCI)
Diabetes
Mammalian sterile20-like kinase (MST1)
Oxidative stress
Nuclear factor erythroid 2-related factor 2 (NRF2)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000806

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http://www.sciencedirect.com/science/article/pii/S2213231724000806

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