Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion

Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion

Abstract Background Cancer progression is influenced by genetic aberrations in the cancer cell population as well as by other factors including the microenvironment present within a tumour. Direct interactions between various cell types as well as cellular signalling via secreted cytokines can drive...

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Bibliographic Details
Main Authors: Sara Rhost, Éamon Hughes, Hannah Harrison, Svanheidur Rafnsdottir, Hanna Jacobsson, Pernilla Gregersson, Ylva Magnusson, Paul Fitzpatrick, Daniel Andersson, Karoline Berger, Anders Ståhlberg, Göran Landberg
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Breast Cancer Research
Subjects:
Cancer stem cells
Breast cancer
Hypoxia
Secretion
Dedifferentiation
Metastasis
Online Access:http://link.springer.com/article/10.1186/s13058-018-1060-5

Internet

http://link.springer.com/article/10.1186/s13058-018-1060-5

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