Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Q<i>β</i> Conjugates as a Vaccine Candidate

Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Q<i>β</i> Conjugates as a Vaccine Candidate

The broadly neutralizing antibody PG9 recognizes a unique glycopeptide epitope in the V1V2 domain of HIV-1 gp120 envelope glycoprotein. The present study describes the design, synthesis, and antibody-binding analysis of HIV-1 V1V2 glycopeptide-Q<i>β</i> conjugates as a mimic of the propo...

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Bibliographic Details
Main Authors: Guanghui Zong, Christian Toonstra, Qiang Yang, Roushu Zhang, Lai-Xi Wang
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
glycopeptide
glycoconjugate
neutralizing epitope
bacteriophage Q<i>β</i>
neutralizing antibody
HIV vaccine
Online Access:https://www.mdpi.com/1422-0067/22/22/12538

Internet

https://www.mdpi.com/1422-0067/22/22/12538

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