The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage

The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage

The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections to carry out pyroptosis. Inadequate activity of the inflammasome has been associated with states of...

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Bibliographic Details
Main Authors: Mohamed Ghait, Shivalee N. Duduskar, Michael Rooney, Norman Häfner, Laura Reng, Bianca Göhrig, Philipp A. Reuken, Frank Bloos, Michael Bauer, Christoph Sponholz, Tony Bruns, Ignacio Rubio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
CASP4
CASP5
NLRP3
sepsis
liver failure
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239474/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239474/full

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