Evidence for Non-Linear Pharmacokinetics of Oxytocin in Anesthetizetized Rat

Purpose: Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. Methods: A single intravenous bolus of OT was given at doses of 200, 300, 500, 10...

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Bibliographic Details
Main Authors: Eric Troncy, Valérie Morin, Jérôme R.E. del Castillo, Simon Authier, Norma Ybarra, Colombe Otis, Dominique Gauvin, Jolanta Gutkowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2008-10-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/4150