CDK12‐inactivation‐induced MYC signaling causes dependency on the splicing kinase SRPK1

CDK12‐inactivation‐induced MYC signaling causes dependency on the splicing kinase SRPK1

Inactivation of cyclin‐dependent kinase 12 (CDK12) characterizes an aggressive sub‐group of castration‐resistant prostate cancer (CRPC). Hyper‐activation of MYC transcription factor is sufficient to confer the CRPC phenotype. Here, we show that loss of CDK12 promotes MYC activity, which renders the...

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Bibliographic Details
Main Authors: Jing Liang, Aishwarya Gondane, Harri M. Itkonen
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Molecular Oncology
Subjects:
cyclin‐dependent kinase 12
prostate cancer
SLAM‐seq
splicing
synthetic lethality
Online Access:https://doi.org/10.1002/1878-0261.13666

Internet

https://doi.org/10.1002/1878-0261.13666

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