Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) increases the risk of Alzheimer’s disease (AD)-like dementia and pathology. Endoplasmic reticulum stress (ERS) plays a key role in the development of cognitive impairment in T2DM. Zonisamide (ZNS) was found to suppress ERS-induced neuronal cell damage in the experimen...

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Bibliographic Details
Main Authors: Yong-Xiang He, Qi-Ying Shen, Jia-Hui Tian, Qian Wu, Qin Xue, Gui-Ping Zhang, Wei Wei, Ying-Hua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Zonisamide
type 2 diabetes mellitus
cognitive impairment
ER stress
Tau
Aβ
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00192/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00192/full

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