One-step synthesis of site-specific antibody–drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates

One-step synthesis of site-specific antibody–drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates

Glycosite-specific antibody‒drug conjugatess (gsADCs), harnessing Asn297 N-glycan of IgG Fc as the conjugation site for drug payloads, usually require multi-step glycoengineering with two or more enzymes, which limits the substrate diversification and complicates the preparation process. Herein, we...

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Bibliographic Details
Main Authors: Wei Shi, Wanzhen Li, Jianxin Zhang, Tiehai Li, Yakai Song, Yue Zeng, Qian Dong, Zeng Lin, Likun Gong, Shuquan Fan, Feng Tang, Wei Huang
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Site-specific ADCs
ENGase
LacNAc
One-step assembly
Potent in vivo efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004858

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http://www.sciencedirect.com/science/article/pii/S2211383521004858

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