Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication

Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication

ABSTRACT Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins. Using a loss-of-function CRISPR screen, we show that synthesis of a flavivirus-encoded fluorescent...

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Bibliographic Details
Main Authors: Maikke B. Ohlson, Jennifer L. Eitson, Alexandra I. Wells, Ashwani Kumar, Seoyeon Jang, Chunyang Ni, Chao Xing, Michael Buszczak, John W. Schoggins
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
RNA virus
flavivirus
ribosomes
translation
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/mbio.00127-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00127-23

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