Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation

Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation

Pulmonary arterial remodeling at an early stage, including excessive proliferation and migration of smooth muscle cells, is a hallmark of pulmonary arterial hypertension (PAH). Salt-inducible kinases (SIKs) have been increasingly reported to play a key role in smooth muscle cell proliferation and ph...

Full description

Bibliographic Details
Main Authors: Jiangqin Pu, Feng Wang, Peng Ye, Xiaomin Jiang, Wenying Zhou, Yue Gu, Shaoliang Chen
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Heliyon
Subjects:
Cell proliferation
Pulmonary arterial hypertension
Vascular remodeling
SIK1
YAP
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022023040

Internet

http://www.sciencedirect.com/science/article/pii/S2405844022023040

Similar Items