Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines

Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines

A series of novel 4-Hydroxyquinazoline derivatives were designed and synthesized to enhance sensitivity in primary PARPi-resistant cells. Among them, the compound <b>B1</b> has been found to have superior cytotoxicity in primary PARPi-resistant HCT-15 and HCC1937 cell lines, and dose-dep...

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Bibliographic Details
Main Authors: Lijie Zhu, Binzhuo Liu, Feng Jin, Weilong Cao, Guangzhao Xu, Xinwei Zhang, Peng Peng, Dingding Gao, Bin Wang, Kairui Feng
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
PARPi
4-Hydroxyquinazoline
anti-tumor
primary drug-resistant
Online Access:https://www.mdpi.com/1420-3049/29/6/1407

Internet

https://www.mdpi.com/1420-3049/29/6/1407

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