Immune checkpoint blockade induced shifts in cytokine expression patterns in peripheral blood of head and neck cancer patients are linked to outcome

Immune checkpoint blockade induced shifts in cytokine expression patterns in peripheral blood of head and neck cancer patients are linked to outcome

BackgroundImmune-checkpoint blockade (ICB) of programmed-death-1 (PD-1) with pembrolizumab or nivolumab is approved for treating recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). NadiHN and ADRISK are phase IIB trials investigating in locally advanced (LA) HNSCC having low or...

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Bibliographic Details
Main Authors: Louisa Röhl, Jana Wellhausen, Michael Berszin, Irene Krücken, Veit Zebralla, Markus Pirlich, Susanne Wiegand, Andreas Dietz, Theresa Wald, Gunnar Wichmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitor-blockade (ICB)
programmed-death 1 (PD-1)
head and neck squamous cell carcinoma (HNSCC)
liquid biopsy
cytokine expression pattern (CEP)
interferon gamma (IFN-γ)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237623/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237623/full

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