µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na<sub>V</sub>1.7

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na<sub>V</sub>1.7

µ-Conotoxins are small, potent, peptide voltage-gated sodium (Na<sub>V</sub>) channel inhibitors characterised by a conserved cysteine framework. Despite promising in vivo studies indicating analgesic potential of these compounds, selectivity towards the therapeutically relevant subtype...

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Bibliographic Details
Main Authors: Kirsten L. McMahon, Hue N. T. Tran, Jennifer R. Deuis, David J. Craik, Irina Vetter, Christina I. Schroeder
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Toxins
Subjects:
µ-conotoxins
voltage-gated sodium channels
structure-activity relationships
disulfide-rich peptides
Cys frameworks
Online Access:https://www.mdpi.com/2072-6651/14/9/600

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https://www.mdpi.com/2072-6651/14/9/600

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