Developing an Improved UHPLC Method for Efficient Determination of European Pharmacopeia Process-Related Impurities in Ropinirole Hydrochloride Using Analytical Quality by Design Principles

Developing an Improved UHPLC Method for Efficient Determination of European Pharmacopeia Process-Related Impurities in Ropinirole Hydrochloride Using Analytical Quality by Design Principles

This article presents the development of a reversed-phase ultra-high-performance liquid chromatographic method for determining process-related impurities in ropinirole hydrochloride drug substance applying the analytical quality by design approach. The current pharmacopeial method suffers from selec...

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Bibliographic Details
Main Authors: Tim Tome, Aleš Obreza, Zdenko Časar
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
AQbD
UHPLC
method development
method optimization
design of experiments
pharmacopeia
Online Access:https://www.mdpi.com/1420-3049/25/11/2691

Internet

https://www.mdpi.com/1420-3049/25/11/2691

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