Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Lymphocyte numbers need to be quite tightly regulated. It is generally assumed that lymphocyte production and lifespan increase homeostatically when lymphocyte numbers are low and, vice versa, return to normal once cell numbers have normalized. This widely accepted concept is largely based on experi...

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Bibliographic Details
Main Authors: Mariona Baliu-Piqué, Vera van Hoeven, Julia Drylewicz, Lotte E van der Wagen, Anke Janssen, Sigrid A Otto, Menno C van Zelm, Rob J de Boer, Jürgen Kuball, Jose AM Borghans, Kiki Tesselaar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
lymphopenia
autologous hematopoietic
stem cell transplantation
lymphocyte dynamics
deuterium labeling
mathematical modeling
Online Access:https://elifesciences.org/articles/59775

Internet

https://elifesciences.org/articles/59775

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