Taxifolin Inhibits the Growth of Non-Small-Cell Lung Cancer via Downregulating Genes Displaying Novel and Robust Associations with Immune Evasion Factors

Taxifolin Inhibits the Growth of Non-Small-Cell Lung Cancer via Downregulating Genes Displaying Novel and Robust Associations with Immune Evasion Factors

Using an LL2 cell-based syngeneic mouse LC model, taxifolin suppressed allografts along with the appearance of 578 differentially expressed genes (DEGs). These DEGs were associated with enhancement of processes related to the extracellular matrix and lymphocyte chemotaxis as well as the reduction in...

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Bibliographic Details
Main Authors: Xiaozeng Lin, Ying Dong, Yan Gu, Fengxiang Wei, Jingyi Peng, Yingying Su, Yanjun Wang, Chengzhi Yang, Sandra Vega Neira, Anil Kapoor, Damu Tang
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
taxifolin
LUAD
LUSC
immune escapes
immune checkpoint blockade
overall survival
Online Access:https://www.mdpi.com/2072-6694/15/19/4818

Internet

https://www.mdpi.com/2072-6694/15/19/4818

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