Rapamycin prevents retinal neovascularization by downregulation of cyclin D1 in a mouse model of oxygen-induced retinopathy

Rapamycin prevents retinal neovascularization by downregulation of cyclin D1 in a mouse model of oxygen-induced retinopathy

Abstract Background Rapamycin (RAPA) is a potent angiogenic inhibitor and the aim of this study is to identify the inhibitory effect of RAPA on retinal neovascularization (RNV) in experimental oxygen-induced retinopathy (OIR). Methods Forty-two 7-day-old C57BL/6 J mice were randomly divided into nor...

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Bibliographic Details
Main Authors: Feng Jiang, Ying Wang, Shufang Du, Heng Jin, Jindong Han
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Ophthalmology
Subjects:
Retinal neovascularization
Prevention
Rapamycin
Cell cycle
Animal experiment
Online Access:https://doi.org/10.1186/s12886-020-1325-5

Internet

https://doi.org/10.1186/s12886-020-1325-5

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