Aberrant Methylation of Somatostatin Receptor 2 Gene Is Initiated in Aged Gastric Mucosa Infected with <i>Helicobacter pylori</i> and Consequential Gene Silencing Is Associated with Establishment of Inflammatory Microenvironment In Vitro Study

Aberrant Methylation of Somatostatin Receptor 2 Gene Is Initiated in Aged Gastric Mucosa Infected with <i>Helicobacter pylori</i> and Consequential Gene Silencing Is Associated with Establishment of Inflammatory Microenvironment In Vitro Study

The loss-of-function variants are thought to be associated with inflammation in the stomach. We here aimed to evaluate the extent and role of methylation at the <i>SSTR2</i> promoter in inflammation and gastric tumor formation. A whole-genome bisulfite sequencing analysis revealed that t...

Full description

Bibliographic Details
Main Authors: Hee-Jin Kim, Jong-Lyul Park, Byoung-Ha Yoon, Keeok Haam, Haejeong Heo, Jong-Hwan Kim, Seon-Young Kim, Mirang Kim, Woo-Ho Kim, Sang-Il Lee, Kyu-Sang Song, Kwang-Sung Ahn, Yong Sung Kim
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
SSTR2
gastric cancer
WGBS
hypermethylation
inflammation
Online Access:https://www.mdpi.com/2072-6694/14/24/6183

Internet

https://www.mdpi.com/2072-6694/14/24/6183

Similar Items