High Doses of ANA12 Improve Phenobarbital Efficacy in a Model of Neonatal Post-Ischemic Seizures

High Doses of ANA12 Improve Phenobarbital Efficacy in a Model of Neonatal Post-Ischemic Seizures

Phenobarbital (PB) remains the first-line medication for neonatal seizures. Yet, seizures in many newborns, particularly those associated with perinatal ischemia, are resistant to PB. Previous animal studies have shown that in postnatal day P7 mice pups with ischemic stroke induced by unilateral car...

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Bibliographic Details
Main Authors: Preeti Vyas, Ira Chaturvedi, Yun Hwang, Joseph Scafidi, Shilpa D. Kadam, Carl E. Stafstrom
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxic-ischemic encephalopathy
neonatal seizures
phenobarbital
ANA12
TrkB
KCC2
Online Access:https://www.mdpi.com/1422-0067/25/3/1447

Internet

https://www.mdpi.com/1422-0067/25/3/1447

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