Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway

Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway

Caffeine has been reported to delay aging and protect aging-associated disorders in Caenorhabditis elegans. However, the effects of low concentration of caffeine and its analogs on lifespan are currently missing. Herein, we report that at much lower concentrations (as low as 10 μg/ml), caffeine exte...

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Bibliographic Details
Main Authors: Xiaocui Du, Yun Guan, Qin Huang, Ming Lv, Xiaofang He, Liang Yan, Shuhei Hayashi, Chongye Fang, Xuanjun Wang, Jun Sheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
caffeine
C. elegans
lifespan
IGF-1 pathway
daf-2
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00211/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00211/full

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