Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype

Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype

Abstract Systemic inflammation and neuroinflammation affect the natural course of the sporadic form of Alzheimer’s disease (AD), as supported by epidemiological and preclinical data, and several epidemiological studies indicate a higher prevalence of AD in patients with inflammatory bowel disease. I...

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Bibliographic Details
Main Authors: Luca Lorenzini, Lorenzo Zanella, Michele Sannia, Vito Antonio Baldassarro, Marzia Moretti, Maura Cescatti, Corinne Quadalti, Simone Baldi, Gianluca Bartolucci, Leandro Di Gloria, Matteo Ramazzotti, Paolo Clavenzani, Anna Costanzini, Roberto De Giorgio, Amedeo Amedei, Laura Calzà, Luciana Giardino
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Astrocytes
Cytokines/chemokines
Gut microbiota/microbiome
Neuroinflammation
Preclinical Alzheimer’s disease
Systemic inflammation
Online Access:https://doi.org/10.1186/s13195-024-01471-2

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https://doi.org/10.1186/s13195-024-01471-2

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