Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study

Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study

Abstract Background Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Biological heterogeneity in recurrent tumors contributes to the different...

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Main Authors: Ting Liu, Di Dong, Xun Zhao, Xiao-Min Ou, Jun-Lin Yi, Jian Guan, Ye Zhang, Lv Xiao-Fei, Chuan-Miao Xie, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Lv Xing, Shan-Shan Guo, Li-Ting Liu, Da-Feng Lin, Yan-Zhou Chen, Jie-Yi Lin, Mei-Juan Luo, Wen-Bin Yan, Mei-Lin He, Meng-Yuan Mao, Man-Yi Zhu, Wen-Hui Chen, Bo-Wen Shen, Shi-Qian Wang, Hai-Lin Li, Lian-Zhen Zhong, Chao-Su Hu, De-Hua Wu, Hai-Qiang Mai, Jie Tian, Lin-Quan Tang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Medicine
Subjects:
Recurrent nasopharyngeal carcinoma
Re-radiotherapy
Nasopharyngeal necrosis
Radiomics
Online Access:https://doi.org/10.1186/s12916-023-03164-3

Internet

https://doi.org/10.1186/s12916-023-03164-3

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