Study of the Structural Chemistry of the Inclusion Complexation of 4-Phenylbutyrate and Related Compounds with Cyclodextrins in Solution: Differences in Inclusion Mode with Cavity Size Dependency

Study of the Structural Chemistry of the Inclusion Complexation of 4-Phenylbutyrate and Related Compounds with Cyclodextrins in Solution: Differences in Inclusion Mode with Cavity Size Dependency

4-phenylbutyrate (PB) and structurally related compounds hold promise for treating many diseases, including cancers. However, pharmaceutical limitations, such as an unpleasant taste or poor aqueous solubility, impede their evaluation and clinical use. This study explores cyclodextrin (CD) complexati...

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Bibliographic Details
Main Authors: Kindness L. Commey, Akari Nakatake, Airi Enaka, Ryota Nakamura, Koji Nishi, Kenji Tsukigawa, Hirohito Ikeda, Koki Yamaguchi, Daisuke Iohara, Fumitoshi Hirayama, Keishi Yamasaki, Masaki Otagiri
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
cyclodextrins
4-phenylbutyrate
inclusion complexation
structural chemistry
inclusion mode
cavity size dependency
Online Access:https://www.mdpi.com/1422-0067/24/20/15091

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https://www.mdpi.com/1422-0067/24/20/15091

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