Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity

Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity

It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex.

Bibliographic Details
Main Authors: Muaz Nik Rushdi, Victor Pan, Kaitao Li, Hyun-Kyu Choi, Stefano Travaglino, Jinsung Hong, Fletcher Griffitts, Pragati Agnihotri, Roy A. Mariuzza, Yonggang Ke, Cheng Zhu
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34587-w

Internet

https://doi.org/10.1038/s41467-022-34587-w

Similar Items