Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34587-w |
| _version_ | 1811217061124243456 |
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| author | Muaz Nik Rushdi Victor Pan Kaitao Li Hyun-Kyu Choi Stefano Travaglino Jinsung Hong Fletcher Griffitts Pragati Agnihotri Roy A. Mariuzza Yonggang Ke Cheng Zhu |
| author_facet | Muaz Nik Rushdi Victor Pan Kaitao Li Hyun-Kyu Choi Stefano Travaglino Jinsung Hong Fletcher Griffitts Pragati Agnihotri Roy A. Mariuzza Yonggang Ke Cheng Zhu |
| author_sort | Muaz Nik Rushdi |
| collection | DOAJ |
| description | It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex. |
| first_indexed | 2024-04-12T06:48:52Z |
| format | Article |
| id | doaj.art-2859ebb5eb6e4438bdcbb90534f57bee |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T06:48:52Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2859ebb5eb6e4438bdcbb90534f57bee2022-12-22T03:43:26ZengNature PortfolioNature Communications2041-17232022-11-0113111610.1038/s41467-022-34587-wCooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivityMuaz Nik Rushdi0Victor Pan1Kaitao Li2Hyun-Kyu Choi3Stefano Travaglino4Jinsung Hong5Fletcher Griffitts6Pragati Agnihotri7Roy A. Mariuzza8Yonggang Ke9Cheng Zhu10Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityParker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of TechnologyW. M. Keck Laboratory for Structural Biology, Institute for Bioscience and Biotechnology Research, University of MarylandW. M. Keck Laboratory for Structural Biology, Institute for Bioscience and Biotechnology Research, University of MarylandWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityIt is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex.https://doi.org/10.1038/s41467-022-34587-w |
| spellingShingle | Muaz Nik Rushdi Victor Pan Kaitao Li Hyun-Kyu Choi Stefano Travaglino Jinsung Hong Fletcher Griffitts Pragati Agnihotri Roy A. Mariuzza Yonggang Ke Cheng Zhu Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity Nature Communications |
| title | Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity |
| title_full | Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity |
| title_fullStr | Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity |
| title_full_unstemmed | Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity |
| title_short | Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity |
| title_sort | cooperative binding of t cell receptor and cd4 to peptide mhc enhances antigen sensitivity |
| url | https://doi.org/10.1038/s41467-022-34587-w |
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