Autophagy Promotes the Survival of Adipose Mesenchymal Stem/Stromal Cells and Enhances Their Therapeutic Effects in Cisplatin-Induced Liver Injury via Modulating TGF-β1/Smad and PI3K/AKT Signaling Pathways

Autophagy Promotes the Survival of Adipose Mesenchymal Stem/Stromal Cells and Enhances Their Therapeutic Effects in Cisplatin-Induced Liver Injury via Modulating TGF-β1/Smad and PI3K/AKT Signaling Pathways

Autophagy is a key metabolic process where cells can recycle its proteins and organelles to regenerate its own cellular building blocks. Chemotherapy is indispensable for cancer treatment but associated with various side-effects, including organ damage. Stem cell-based therapy is a promising approac...

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Bibliographic Details
Main Authors: Eman Mohamad El Nashar, Mansour Abdullah Alghamdi, Wardah Abdullah Alasmari, Mohamed M. A. Hussein, Eman Hamza, Reham Ismail Taha, Mona M. Ahmed, Khulood Mohammed Al-Khater, Ahmed Abdelfattah-Hassan
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
ADSCs
cell-based therapy
rapamycin
apoptosis
liver damage
hepatoprotective pathways
Online Access:https://www.mdpi.com/2073-4409/10/9/2475

Internet

https://www.mdpi.com/2073-4409/10/9/2475

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