Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation.

Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation.

The gene therapy field is currently limited by the lack of vehicles that permit efficient gene delivery to specific cell or tissue subsets. Native viral vector tropisms offer a powerful platform for transgene delivery but remain nonspecific, requiring elevated viral doses to achieve efficacy. In ord...

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Bibliographic Details
Main Authors: Michael O Alberti, Justin C Roth, Mourad Ismail, Yuko Tsuruta, Edward Abraham, Larisa Pereboeva, Stanton L Gerson, David T Curiel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3356302?pdf=render

Internet

http://europepmc.org/articles/PMC3356302?pdf=render

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