Vitamin combination promotes ex vivo expansion of NK-92 cells by reprogramming glucose metabolism

Vitamin combination promotes ex vivo expansion of NK-92 cells by reprogramming glucose metabolism

Abstract Robust ex vivo expansion of NK-92 cells is essential for clinical immunotherapy. The vitamin B group is critical for the expansion and function of immune cells. This study optimized a vitamin combination by response surface methodology based on an in-house designed chemically defined serum-...

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Bibliographic Details
Main Authors: Yan Fu, Yuying Chen, Zhepei Xie, Huimin Huang, Wen-Song Tan, Haibo Cai
Format: Article
Language:English
Published: SpringerOpen 2022-08-01
Series:Bioresources and Bioprocessing
Subjects:
NK-92 cells
Ex vivo expansion
Response surface methodology
Vitamin concentration optimization
Glucose metabolism
Online Access:https://doi.org/10.1186/s40643-022-00578-4

Internet

https://doi.org/10.1186/s40643-022-00578-4

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