TMEM123 a key player in immune surveillance of colorectal cancer

TMEM123 a key player in immune surveillance of colorectal cancer

Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells determines the balance between tumor elimination or outgrowth. We discovered that the protein TMEM123 is over-expressed in tumour-infiltrating CD4 an...

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Main Authors: Elisa Pesce, Chiara Cordiglieri, Mauro Bombaci, Serenella Eppenberger-Castori, Stefania Oliveto, Cristina Manara, Mariacristina Crosti, Caner Ercan, Mairene Coto, Andrea Gobbini, Susanna Campagnoli, Tiziano Donnarumma, Manuele Martinelli, Valeria Bevilacqua, Elisa De Camilli, Paola Gruarin, Maria L. Sarnicola, Elisa Cassinotti, Ludovica Baldari, Giuseppe Viale, Stefano Biffo, Sergio Abrignani, Luigi M. Terracciano, Renata Grifantini
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
tumor microenvironment
tumor-infiltrating lymphocytes
TMEM123
cytoskeleton organization
cell adhesion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194087/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194087/full

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