PAR1 and PAR4 exert opposite effects on tumor growth and metastasis of esophageal squamous cell carcinoma via STAT3 and NF-κB signaling pathways

PAR1 and PAR4 exert opposite effects on tumor growth and metastasis of esophageal squamous cell carcinoma via STAT3 and NF-κB signaling pathways

Abstract Background Esophageal carcinogenesis is a multifactorial process in which genetic and environmental factors interact to activate intracellular signals, leading to the uncontrolled survival and growth of esophageal squamous cell carcinoma (ESCC) cells. The intracellular pathways of ESCC cell...

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Bibliographic Details
Main Authors: Jia Zhao, Guangyu Jin, Xudong Liu, Kai Wu, Yang Yang, Zhanfeng He, Donglei Liu, Chunyang Zhang, Dengyan Zhu, Jia Jiao, Xiangnan Li, Song Zhao
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cancer Cell International
Subjects:
Esophageal squamous cell carcinoma
Protease-activated receptors
Cancer metastasis
STAT3/NF-κB
Online Access:https://doi.org/10.1186/s12935-021-02354-4

Internet

https://doi.org/10.1186/s12935-021-02354-4

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