Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

Advancing age causes reduced hippocampal neurogenesis, associated with age-related cognitive decline. The spatial relationship of age-induced alterations in neural stem cells (NSCs) and surrounding cells within the hippocampal niche remains poorly understood due to limitations of antibody-based cell...

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Bibliographic Details
Main Authors: John Darby Cole, Jacobo Sarabia del Castillo, Gabriele Gut, Daniel Gonzalez-Bohorquez, Lucas Pelkmans, Sebastian Jessberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/68000