Double-dose icotinib may induce the emergence of the EGFR exon 20 T790M mutation in non-small cell lung cancer patients harboring EGFR-sensitive mutation

Double-dose icotinib may induce the emergence of the EGFR exon 20 T790M mutation in non-small cell lung cancer patients harboring EGFR-sensitive mutation

BackgroundAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) inevitably occurs in non-small cell lung cancer (NSCLC) patients harboring EGFR-sensitive mutations. There are approximately half of the patients who developed resistance to EGFR-TKIs treatment,...

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Bibliographic Details
Main Authors: Jianxin Chen, Xilin Wu, Junhui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
icotinib
double dose
T790M mutation
lung cancer
epidermal growth factor receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.898586/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.898586/full

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