Pan-cancer analysis reveals PDK family as potential indicators related to prognosis and immune infiltration

Pan-cancer analysis reveals PDK family as potential indicators related to prognosis and immune infiltration

Abstract Pyruvate dehydrogenase kinases (PDKs) play a key role in glucose metabolism by exerting negative regulation over pyruvate dehyrogenase complex (PDC) activity through phosphorylation. Inhibition of PDKs holds the potential to enhance PDC activity, prompting cells to adopt a more aerobic meta...

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Bibliographic Details
Main Authors: Shigui Tao, Kunlin Tao, Xiaoyong Cai
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
PDK family
Pan-cancer
Survival analysis
Immune infiltration
Therapeutic target
Online Access:https://doi.org/10.1038/s41598-024-55455-1

Internet

https://doi.org/10.1038/s41598-024-55455-1

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