Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

Patients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies that bind DNA and the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor...

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Bibliographic Details
Main Authors: Eric H. Chang, Bruce T. Volpe, Meggan Mackay, Cynthia Aranow, Philip Watson, Czeslawa Kowal, Justin Storbeck, Paul Mattis, RoseAnn Berlin, Huiyi Chen, Simone Mader, Tomás S. Huerta, Patricio T. Huerta, Betty Diamond
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:EBioMedicine
Subjects:
Lupus
Neuropsychiatric lupus
CA1 place cell
Hippocampus
Mouse lupus model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300293

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http://www.sciencedirect.com/science/article/pii/S2352396415300293

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