Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass

Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass

Previously we utilized a murine model to demonstrate that Ogt deletion in pancreatic progenitors (OgtKO<sup>Panc</sup>) causes pancreatic hypoplasia, partly mediated by a reduction in the Pdx1-expressing pancreatic progenitor pool. Here, we continue to explore the role of Ogt in pancreas...

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Bibliographic Details
Main Authors: Alicia Wong, Brian Akhaphong, Daniel Baumann, Emilyn U. Alejandro
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomedicines
Subjects:
<i>O</i>-GlcNAc
Pdx1
development
β-cells
pancreas
Online Access:https://www.mdpi.com/2227-9059/11/1/105

Internet

https://www.mdpi.com/2227-9059/11/1/105

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