Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography

Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography

Phosphodiesterase 2A (PDE2A) is highly and specifically expressed in particular brain regions that are affected by neurological disorders and in certain tumors. Development of a specific PDE2A radioligand would enable molecular imaging of the PDE2A protein via positron emission tomography (PET). Her...

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Bibliographic Details
Main Authors: Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Ute Egerland, Mathias Kranz, Matthias Scheunemann, Norbert Höfgen, Jörg Steinbach, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
PDE2A
Alzheimer’s disease
PET imaging in brain
micellar HPLC
Online Access:http://www.mdpi.com/1420-3049/20/6/9591

Internet

http://www.mdpi.com/1420-3049/20/6/9591

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