ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation

ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation

Abstract Lung cancer is the most lethal malignancies with high aggressive and poor prognosis. Until now, the five-year survival rate has not been improved which brings serious challenge to human health. Lung cancer stem cells (LCSCs) serve as the root of cancer occurrence, progression, recurrence, a...

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Bibliographic Details
Main Authors: Huiting Deng, Hailin Liu, Guoyue Yang, Dandan Wang, Ying Luo, Chenglong Li, Zhenchang Qi, Zhili Liu, Peng Wang, Yanfang Jia, Yingtang Gao, Yahui Ding
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00462-6

Internet

https://doi.org/10.1038/s41389-023-00462-6

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