Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

Abstract Background Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3.2) regulates neuronal excitability and plays important roles in pain processing. We previously identified that enhanced T-ty...

Full description

Bibliographic Details
Main Authors: Brandon Itson-Zoske, Seung Min Shin, Hao Xu, Chensheng Qiu, Fan Fan, Quinn H. Hogan, Hongwei Yu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Arthritis Research & Therapy
Subjects:
Monosodium iodoacetate
Osteoarthritis
Chronic pain
Dorsal root ganglia
Primary sensory neuron
T-type/Cav3.2 channels
Online Access:https://doi.org/10.1186/s13075-022-02856-0

Internet

https://doi.org/10.1186/s13075-022-02856-0

Similar Items