Enhanced anti-glioma efficacy of doxorubicin with BRD4 PROTAC degrader using targeted nanoparticles

Enhanced anti-glioma efficacy of doxorubicin with BRD4 PROTAC degrader using targeted nanoparticles

Current treatment of glioma is hampered due to the physical blood-brain barrier (BBB) and the resistance to traditional chemotherapeutic agents. Herein, we proposed a combined treatment strategy based on Cyclo (Arg-Gly-Asp-d-Phe-Lys) (cRGDfk) peptides-modified nanoparticle named cRGD-P in a self-ass...

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Bibliographic Details
Main Authors: Yihong He, Xin Zan, Junming Miao, Bilan Wang, Yin Wu, Yangmei Shen, Xinchuan Chen, Hongfeng Gou, Songping Zheng, Ning Huang, Yongzhong Cheng, Yan Ju, Xianghui Fu, Zhiyong Qian, Peizhi Zhou, Jiagang Liu, Xiang Gao
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials Today Bio
Subjects:
Glioma
Resistance
cRGD-PEG-PLA
Doxorubicin
BRD4 PROTAC degrader
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422002216

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http://www.sciencedirect.com/science/article/pii/S2590006422002216

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