New control of the senescence barrier in breast cancer

Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the contro...

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Bibliographic Details
Main Authors: Tânia D. F. Costa, Staffan Strömblad
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2019.1684129